Acquired Mls-1a-like clonal deletion in Mls-1b mice.

Acquired Mls-1a-like clonal deletion in Mls-1b mice

BALB/c mice (H-2d, Mls-1b) from one colony progressively modify their T cell repertoire during aging, by deleting T cells that express products of the V beta 6 and V beta 8.1 genes of the T cell receptor. Clonal deletion occurs only in 50% of mice between 27 and 43 wk of age, affecting thymus, spleen, and lymph node T cells. The phenomenon is progressive and seems to affect nearly all thymuses ...

Acquired Mls - la - like Clonal Deletion in MIs - 1 b Mice

Sllmmal'y BALB/c mice (H-2 d, Mls-1 b) from one colony progressively modify their T cell repertoire during aging, by deleting T cells that express products of the V~6 and V~8.1 genes of the T cell receptor. Clonal deletion occurs only in 50% of mice between 27 and 43 wk of age, affecting thymus, spleen, and lymph node T cells. The phenomenon is progressive and seems to affect nearly all thymuse...

CD4 expression is differentially required for deletion of MLS-1a- reactive T cells

Clonal deletion of thymocytes expressing potentially self-reactive T cell receptors (TCRs) occurs during thymocyte ontogeny. Mice deficient for CD4 expression provide a unique model system to study the contribution of the CD4 molecule in negative selection of T cells reactive against the major histocompatibility complex class II-associated retroviral self-superantigen, Mls-1a. In the presence o...

CD8+ T cells respond clonally to Mls-1a-encoded determinants

T cell responses to the product of the minor lymphocyte stimulatory locus Mls-1a involve the selective use of TCR V beta domains (especially V beta 6 and V beta 8.1) and are generally considered to be restricted to the CD4+ mature subset. We show here that CD8+ (presumably MHC class I-restricted) T cells bearing V beta 6 or V beta 8.1 also respond preferentially to Mls-1a determinants either in...

Microwave Limb Sounder ( MLS ) EOS MLS Level 1 Data Processing